Article
Myogenin is required for late but not early aspects of myogenesis during mouse development.
The Journal of cell biology - 1 Feb 1995
Venuti J M, Morris J H, Vivian J L, Olson E N, Klein W H
Abstract excerpt
Mice with a targeted mutation in the myogenic basic helix-loop-helix regulatory protein myogenin have severe muscle defects resulting in perinatal death. In this report, the effect of myogenin's absence on embryonic and fetal development is investigated. The initial events of somite differentiation occurred normally in the myogenin-mutant embryos. During primary myogenesis, muscle masses in mutant embryos...
Topics
- Animals
- Base Sequence
- Cell Adhesion Molecules
- Cell Differentiation
- Desmin
- Extremities
- Gene Expression
- Histocompatibility Antigens
- Immunohistochemistry
- In Situ Hybridization
- Mice