Article
MRF4 can substitute for myogenin during early stages of myogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 1997
Zhu Z, Miller J B
Abstract excerpt
MRF4, myogenin, MyoD, and Myf-5 are the four members of the basic helix-loop-helix family of muscle-specific regulatory factors (MRFs). We examined whether MRF4 could substitute for myogenin in vivo by determining if the myofiber- and MRF4-deficient phenotype of myogenin (-/-) mice could be rescued by a myogenin promoter-MRF4 transgene. When the transgene was expressed at a physiological level in...
Topics
- Animals
- Gene Expression Regulation, Developmental
- Mice
- Mice, Transgenic
- Muscle Fibers, Skeletal
- Muscles
- MyoD Protein
- Myogenic Regulatory Factors
- Myogenin
- Phenotype
- Promoter Regions, Genetic
- Receptors, Cholinergic
- Transcription Factors
- Transgenes