Article
Evidence for a novel type 1 diabetes susceptibility locus on chromosome 8.
Diabetes - 1 Dec 2002
Sale Michèle M, FitzGerald Liesel M, Charlesworth Jacinta C, Bowden Donald W, Rich Stephen S
Abstract excerpt
Type 1 diabetes results from a combination of genetic susceptibility and environmental exposures. Susceptibility loci other than HLA and the insulin gene remain to be identified to account for the degree of familial clustering observed in this disorder. Early genome-wide scans provided suggestive evidence of linkage on chromosome 8q, prompting detailed analysis of this region. A total of 20 microsatellite markers...
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