Article
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
Nature genetics - 1 Jul 2007
Todd John A, Walker Neil M, Cooper Jason D, Smyth Deborah J, Downes Kate, Plagnol Vincent, Bailey Rebecca, Nejentsev Sergey, Field Sarah F, Payne Felicity, Lowe Christopher E, Szeszko Jeffrey S, Hafler Jason P, Zeitels Lauren, Yang Jennie H M, Vella Adrian, Nutland Sarah, Stevens Helen E, Schuilenburg Helen, Coleman Gillian, Maisuria Meeta, Meadows William, Smink Luc J, Healy Barry, Burren Oliver S, Lam Alex A C, Ovington Nigel R, Allen James, Adlem Ellen, Leung Hin-Tak, Wallace Chris, Howson Joanna M M, Guja Cristian, Ionescu-Tîrgovişte Constantin, Simmonds Matthew J, Heward Joanne M, Gough Stephen C L, Dunger David B, Wicker Linda S, Clayton David G
Abstract excerpt
The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls...
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