Article
Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.
American journal of human genetics - 1 Jan 1997
Delépine M, Pociot F, Habita C, Hashimoto L, Froguel P, Rotter J, Cambon-Thomsen A, Deschamps I, Djoulah S, Weissenbach J, Nerup J, Lathrop M, Julier C
Abstract excerpt
Linkage studies have led to the identification of several chromosome regions that may contain susceptibility loci to type I diabetes (IDDM), in addition to the HLA and INS loci. These include two on chromosome 6q, denoted IDDM5 and IDDM8, that are not linked to HLA. In a previous study, we notice...
Topics
- Adult
- Age of Onset
- Chromosomes, Human, Pair 6
- Diabetes Mellitus, Type 1
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- HLA Antigens
- Humans
- Major Histocompatibility Complex
- Male
- Microsatellite Repeats
- Sex Characteristics