Article
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.
Diabetes - 1 Apr 2009
Concannon Patrick, Chen Wei-Min, Julier Cécile, Morahan Grant, Akolkar Beena, Erlich Henry A, Hilner Joan E, Nerup Jørn, Nierras Concepcion, Pociot Flemming, Todd John A, Rich Stephen S
Abstract excerpt
OBJECTIVE: Type 1 diabetes arises from the actions of multiple genetic and environmental risk factors. Considerable success at identifying common genetic variants that contribute to type 1 diabetes risk has come from genetic association (primarily case-control) studies. However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to disease risk....
Topics
- Chromosome Mapping
- Chromosomes, Human
- Chromosomes, Human, Pair 17
- Chromosomes, Human, X
- Diabetes Mellitus, Type 1
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Variation
- Genome, Human
- Genotype
- HLA Antigens
- Humans