Article
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.
The EMBO journal - 1 Apr 1998
Scharenberg A M, El-Hillal O, Fruman D A, Beitz L O, Li Z, Lin S, Gout I, Cantley L C, Rawlings D J, Kinet J P
Abstract excerpt
Tec family non-receptor tyrosine kinases have been implicated in signal transduction events initiated by cell surface receptors from a broad range of cell types, including an essential role in B-cell development. A unique feature of several Tec members among known tyrosine kinases is the presence...
Topics
- Agammaglobulinaemia Tyrosine Kinase
- Animals
- Blood Proteins
- Calcium
- Cell Line, Transformed
- Enzyme Activation
- Enzyme Inhibitors
- Fibroblasts
- Inositol Phosphates
- Isoenzymes
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates