Article

Disrupted Ca<sup>2+</sup> homeostasis and immunodeficiency in patients with functional Inositol 1,4,5-trisphosphate receptor subtype 3 defects

2021-06-08

Abstract excerpt

Calcium signaling is essential for lymphocyte activation, with genetic disruptions resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP 3 R), formed from homo- or hetero-tetramers of the IP 3 R isoforms 1-3, amplifies lymphocyte signaling by releasing Ca 2+ from ER stores into the cytosol following antigen-stimulation. While knockout of all 3 IP 3 R isoforms results in immunodeficien...

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Literature Corpus work: 1af756f7-ae12-5746-aa5d-c1d6b6443550
DOI: 10.1101/2021.05.29.21257775

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