Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2006

Hoek Kristen L, Antony Pierre, Lowe John, Shinners Nicholas, Sarmah Bhaskarjyoti, Wente Susan R, Wang Demin, Gerstein Rachel M, Khan Wasif N

Abstract excerpt

Functional peripheral mature follicular B (FoB) lymphocytes are thought to develop from immature transitional cells in a BCR-dependent manner. We have previously shown that BCR cross-linking in vitro results in death of early transitional (T1) B cells, whereas late transitional (T2) B cells survive and display phenotypic characteristics of mature FoB cells. We now demonstrate that diacylglycerol (DAG), a lipid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Cell Survival

Share to Diglycerides

Share to Lymphocyte Subsets

Share to Mice, Knockout

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 17015726
DOI: 10.4049/jimmunol.177.8.5405

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement.PMID 17015726Read ↗

Transitional B cells: step by step towards immune competence.Semantic proximity Read ↗

Novel human transitional B cell populations revealed by B cell depletion therapy.Semantic proximity Read ↗

Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.Semantic proximity Read ↗

Generation of peripheral B cells occurs via two spatially and temporally distinct pathways.Semantic proximity Read ↗

Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation.Semantic proximity Read ↗

B cell antigen receptor-induced Rac1 activation and Rac1-dependent spreading are impaired in transitional immature B cells due to levels of membrane cholesterol.Semantic proximity Read ↗

Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile.Semantic proximity Read ↗

BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells.Semantic proximity Read ↗

Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha.Semantic proximity Read ↗

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.Semantic proximity Read ↗

Protein Kinase Cδ Promotes Transitional B Cell-Negative Selection and Limits Proximal B Cell Receptor Signaling To Enforce ToleranceSemantic proximity Read ↗

Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.