Article
Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2006
Hoek Kristen L, Antony Pierre, Lowe John, Shinners Nicholas, Sarmah Bhaskarjyoti, Wente Susan R, Wang Demin, Gerstein Rachel M, Khan Wasif N
Abstract excerpt
Functional peripheral mature follicular B (FoB) lymphocytes are thought to develop from immature transitional cells in a BCR-dependent manner. We have previously shown that BCR cross-linking in vitro results in death of early transitional (T1) B cells, whereas late transitional (T2) B cells survive and display phenotypic characteristics of mature FoB cells. We now demonstrate that diacylglycerol (DAG), a lipid...
Topics
- Animals
- B-Lymphocytes
- Calcium Signaling
- Cell Differentiation
- Cell Survival
- Diglycerides
- Lymphocyte Subsets
- Mice
- Mice, Knockout
- Phenotype
- Receptors, Antigen, B-Cell
- Signal Transduction