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Article

Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes.

Cellular signalling - 1 Oct 2005

Wain Clare M, Westwick John, Ward Stephen G

Abstract excerpt

The SH2 domain-containing inositol polyphosphate 5-phosphatase (SHIP) is known to play an important role in the negative regulation by FcgammaRIIB of PI3K-dependent signaling cascades activated by the B cell antigen receptor (BCR) as well as several tyrosine-kinase coupled cytokine receptors. However, to date the role of SHIP in the regulation of PI3K-dependent signals elicited by G-protein-coupled receptors...

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Share to CD2 Antigens
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Share to Chemokines, CXC

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Share to Phosphatidylinositols

Share to Receptors, Antigen, B-Cell

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Source

Identifiers

PMID: 16038794
DOI: 10.1016/j.cellsig.2004.12.009

Genes

CXCL12
BCR
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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