Article
Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes.
Cellular signalling - 1 Oct 2005
Wain Clare M, Westwick John, Ward Stephen G
Abstract excerpt
The SH2 domain-containing inositol polyphosphate 5-phosphatase (SHIP) is known to play an important role in the negative regulation by FcgammaRIIB of PI3K-dependent signaling cascades activated by the B cell antigen receptor (BCR) as well as several tyrosine-kinase coupled cytokine receptors. However, to date the role of SHIP in the regulation of PI3K-dependent signals elicited by G-protein-coupled receptors...
Topics
- Animals
- CD2 Antigens
- Cell Line, Tumor
- Chemokine CXCL12
- Chemokines, CXC
- Chemotaxis
- Extracellular Signal-Regulated MAP Kinases
- Humans
- Immunoglobulin G
- Jurkat Cells
- Lymphocytes
- Mice
- Mutation
- Phosphatidylinositol 3-Kinases