Article
p53 gene mutations in multiple myeloma.
Molecular pathology : MP - 1 Feb 1997
Owen R G, Davis S A, Randerson J, Rawstron A C, Davies F, Child J A, Jack A S, Morgan G J
Abstract excerpt
AIM: To assess whether p53 gene mutation is important in the pathogenesis and progression of multiple myeloma. METHODS: Thirty eight DNA samples (derived predominantly from bone marrow) obtained from 31 patients with multiple myeloma were examined for mutations in p53 exons 5-9 by polymerase chain reaction single strand conformation polymorphism. Twenty three samples were analysed at the time of diagnosis (one...
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