Article
N-ras and p53 gene mutations are very rare events in multiple myeloma.
International journal of hematology - 1 Aug 1995
Yasuga Y, Hirosawa S, Yamamoto K, Tomiyama J, Nagata K, Aokia N
Abstract excerpt
The frequencies of p53 and N-ras gene mutations were examined in multiple myeloma. DNA samples of 45 cases of multiple myeloma were obtained from stored bone marrow smears. All samples were analyzed for the N-ras gene at codon 12 by the allele specific restriction analysis method and at codon 61 by direct sequencing. DNA was screened for mutations by single-strand conformation polymorphism analysis for the p53...
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