Article
Mutations of the p53 gene in human myeloma cell lines.
Oncogene - 1 May 1992
Mazars G R, Portier M, Zhang X G, Jourdan M, Bataille R, Theillet C, Klein B
Abstract excerpt
Mutations affecting the p53 gene have been found associated with many human malignancies, but little is as yet known about multiple myeloma. We investigated p53 gene alterations in 10 human myeloma cell lines (HMCL), half of these being dependent upon exogenous interleukin 6 (IL-6) for in vitro growth, similar to freshly explanted myeloma cells. Using a polymerase chain reaction-single-strand conformation...
Topics
- Base Sequence
- Cell Line
- Genes, p53
- Humans
- Interleukin-6
- Molecular Sequence Data
- Multiple Myeloma
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- RNA
- Transcription, Genetic