Sporadic mutations of the p53 gene in multiple myeloma and no evidence for germline mutations in three familial multiple myeloma pedigrees.

Article

Sporadic mutations of the p53 gene in multiple myeloma and no evidence for germline mutations in three familial multiple myeloma pedigrees.

Leukemia - 1 Jul 1993

Willems P M, Kuypers A W, Meijerink J P, Holdrinet R S, Mensink E J

Abstract excerpt

The recent finding that eight out of 10 multiple myeloma cell lines have p53 gene mutations prompted us to examine the p53 tumour suppressor gene in 25 non-related multiple myeloma patients. None of 19 patient bone marrow samples available for Southern blot analysis showed rearrangements in the p...

Topics

Adult
Aged
Base Sequence
Female
Gene Deletion
Genes, p53
Humans
Male
Middle Aged
Molecular Sequence Data
Multiple Myeloma
Mutation
Oligodeoxyribonucleotides
Pedigree

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