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Article

Oncogenes in multiple myeloma: point mutation of N-ras.

Oncogene - 1 Nov 1990

Paquette R L, Berenson J, Lichtenstein A, McCormick F, Koeffler H P

Abstract excerpt

Alterations of ras, c-myc and bcl-1 have been described in hematologic malignancies of lymphoid origin. We investigated the structure of these genes and evaluated the frequency of point mutations involving H-, K- or N-ras in bone marrow samples from patients with multiple myeloma. No abnormalities were detected in the c-myc and bcl-1 genes, but two of 17 patients were found to have N-ras mutations by differential...

Topics

Base Sequence
Bone Marrow
Genes, ras
Humans
Male
Middle Aged
Multiple Myeloma
Mutation
Nucleic Acid Hybridization
Oligonucleotide Probes
Oncogenes
Plasma Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Source

Identifiers

PMID: 2267133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2267133-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Oncogenes in multiple myeloma: point mutation of N-ras.PMID 2267133Read ↗

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