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Article

p53 and RAS gene mutations in multiple myeloma.

Oncogene - 1 Dec 1992

Portier M, Molès J P, Mazars G R, Jeanteur P, Bataille R, Klein B, Theillet C

Abstract excerpt

We analysed genomic DNA from 30 patients with multiple myeloma (MM), searching for alterations in the p53 and RAS genes by a combination of polymerase chain reaction and single-strand conformation polymorphism techniques. Mutations in the p53 gene were observed in 20% (6 out of 30) of the patients, and were located in conserved sequence blocks within exons 5 and 7. These were single-nucleotide substitutions and...

Topics

Amino Acid Sequence
Base Sequence
Codon
Exons
Genes, p53
Genes, ras
Humans
Molecular Sequence Data
Multiple Myeloma
Mutation
Neoplasm Staging
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotides, Antisense

Polymerase Chain Reaction

Polymorphism, Genetic

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 1461658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1461658-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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