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Article

Gene abnormalities in multiple myeloma; the relevance of TP53, MDM2, and CDKN2A.

Haematologica - 1 May 2003

Elnenaei Manal O, Gruszka-Westwood Alicja M, A'Hernt Roger, Matutes Estella, Sirohi Bhawna, Powles Ray, Catovsky Daniel

Abstract excerpt

BACKGROUND AND OBJECTIVES: Disruption of either the p14ARF- mdm2- p53 or p16INK4A- Rb1 pathways produces a breakdown of regulatory mechanisms and creates a gateway for tumorigenesis. Since the incidence and clinical implications of abnormalities of TP53, CDKN2A (encoding for p16 and p14) and MDM2 genes (chromosome 12) in multiple myeloma (MM) is not clear, we investigated allelic loss at the former two loci and...

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PMID: 12745272

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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