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Article

Rare occurrence of P53 gene mutations in multiple myeloma.

British journal of haematology - 1 Jul 1992

Preudhomme C, Facon T, Zandecki M, Vanrumbeke M, Laï J L, Nataf E, Loucheux-Lefebvre M H, Kerckaert J P, Fenaux P

Abstract excerpt

We looked for mutations of exons 5-8 of the P53 gene in bone marrow cell from 37 cases of multiple myeloma, using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis and DNA sequencing. 25 patients also had cytogenetic analysis. A point mutation, leading to an am...

Topics

Base Sequence
Bone Marrow
Cells, Cultured
DNA
Exons
Genes, p53
Humans
Molecular Sequence Data
Multiple Myeloma
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1390218
DOI: 10.1111/j.1365-2141.1992.tb08253.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1390218-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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