Article
Multiple myeloma: monoallelic deletions of the tumor suppressor genes TP53 and RB1 in long-term follow-up.
Cancer genetics and cytogenetics - 1 Feb 2000
Carlebach M, Amiel A, Gaber E, Radnay J, Manor Y, Fejgin M, Lishner M
Abstract excerpt
Recently, a working-model of a stepwise malignant transformation in the molecular pathogenesis of multiple myeloma (MM) was proposed, involving the tumor suppressor gene TP53 and retinoblastoma gene (RB1) as prominent components of cell cycle control. To further define the role of TP53 and RB1 in disease progression, we retrospectively analyzed by fluorescence in situ hybridization (FISH) cytological material...
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