Article
Comprehensive allelotyping of well-differentiated human hepatocellular carcinoma with semiquantitative determination of chromosomal gain or loss.
Genes, chromosomes & cancer - 1 Dec 2002
Nishimura Takafumi, Nishida Naoshi, Itoh Teruaki, Kuno Masato, Minata Mutsuko, Komeda Toshiki, Fukuda Yoshihiro, Ikai Iwao, Yamaoka Yoshio, Nakao Kazuwa
Abstract excerpt
Allelic imbalance (AI), which represents certain chromosomal gains or losses, has been described in human hepatocellular carcinoma (HCC), but the impact of AI on the early stage of hepatocarcinogenesis has not been fully clarified. Moreover, no previous allelotype studies have identified the difference in chromosomal gain and loss that results in AI. To resolve these problems, we examined 18 well-differentiated...
Topics
- Aged
- Alleles
- Allelic Imbalance
- Carcinoma, Hepatocellular
- Cell Differentiation
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Chromosome Deletion
- Female
- Gene Amplification