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Article

A late wave of melanoblast differentiation and rostrocaudal migration revealed in patch and rump-white embryos.

Mechanisms of development - 1 Apr 2000

Jordan S A, Jackson I J

Abstract excerpt

Melanocytes originate from a small number of precursors localized either side of the dorsal midline. The tyrosine kinase receptor Kit and its ligand Mgf (Steel Factor) are essential for melanoblast survival and proliferation during their migration from the neural crest. Inappropriate Kit expression in the dermatome and dermis of patch and rump-white mouse mutants apparently sequester Mgf, inhibiting melanoblast...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10727853
DOI: 10.1016/s0925-4773(99)00332-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A late wave of melanoblast differentiation and rostrocaudal migration revealed in patch and rump-white embryos.PMID 10727853Read ↗

Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo.Semantic proximity Read ↗

Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor.Semantic proximity Read ↗

Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine development.Semantic proximity Read ↗

The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice.Semantic proximity Read ↗

Meningeal Melanocytes in the Mouse: Distribution and Dependence on MitfSemantic proximity Read ↗

Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway.Semantic proximity Read ↗

Steel and c-kit in the development of avian melanocytes: a study of normally pigmented birds and of the hyperpigmented mutant silky fowl.Semantic proximity Read ↗

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Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders.Semantic proximity Read ↗

Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant mice.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

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