Article
The Role of the Microenvironment on the Localization of Hair and Skin Nonuniform Pigmented Spots in Mice with a Targeted Mutation in the Endothelin B Receptor.
The Journal of investigative dermatology - 1 May 2026
Li Huirong, Chen Yu, Su Zhongyuan, Wang Jing, Lin Shiwen, Yang Zhifan, Yang Shanshan, Liu Bo, Hou Ling
Abstract excerpt
In mammals, severe mutations in genes controlling melanocyte development, such as Mitf, which encodes a transcription factor, often result in the complete loss of pigmentation in the skin and eyes. However, null mutations in the gene encoding the EDNRB (endothelin B receptor) allow for the appearance of pigmented spots rostrally and caudally. In this study, we show that the microenvironment dictates the local...
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