Article
Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently.
Mechanisms of development - 1 Jan 1998
Nakayama A, Nguyen M T, Chen C C, Opdecamp K, Hodgkinson C A, Arnheiter H
Abstract excerpt
The mouse microphthalmia (Mitf) gene encodes a basic-helix-loop-helix-zipper transcription factor whose mutations are associated with abnormalities in neuroepithelial and neural crest-derived melanocytes. In wild type embryos, Mitf expression in neuropithelium and neural crest precedes that of th...
Topics
- Animals
- Cell Differentiation
- DNA-Binding Proteins
- Deafness
- Female
- Gene Expression Regulation, Developmental
- Genetic Markers
- Helix-Loop-Helix Motifs
- Humans
- Male
- Melanocytes
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Microphthalmia-Associated Transcription Factor
- Mutation
- Nervous System
- Neural Crest