Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients.

Stroke - 1 Feb 2006

Ho Grace Y-H, Eikelboom John W, Hankey Graeme J, Wong Chen-Ru, Tan Siew-Li, Chan Jesscia B-C, Chen Christopher P L-H

Abstract excerpt

BACKGROUND AND PURPOSE: Increased plasma total homocysteine (tHcy) levels are a risk factor for stroke and can be reduced with vitamin therapy. However, data on the tHcy-lowering effects of vitamins are limited largely to white populations. Thus, we aimed to determine in Singaporean patients with recent stroke: (1) the efficacy of vitamin therapy (folic acid, vitamin B12, and B6) on lowering tHcy, and (2) whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dietary Supplements
Share to Hyperhomocysteinemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ischemic Attack, Transient

Share to Placebos

Share to Singapore

Share to Vitamin B 12

Share to Vitamin B 6

Share to Vitamins

Source

Identifiers

PMID: 16397167
DOI: 10.1161/01.STR.0000199845.27512.84

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients.PMID 16397167Read ↗

Homocysteine and Stroke Risk: Modifying Effect of Methylenetetrahydrofolate Reductase C677T Polymorphism and Folic Acid Intervention.Semantic proximity Read ↗

A prospective cohort study of MTHFR C677T gene polymorphism and its influence on the therapeutic effect of homocysteine in stroke patients with hyperhomocysteinemia.Semantic proximity Read ↗

MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.Semantic proximity Read ↗

Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization studySemantic proximity Read ↗

Homocysteine, MTHFR 677C-->T polymorphism, and risk of ischemic stroke: results of a meta-analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and ischemic stroke in Tunisian patients.Semantic proximity Read ↗

MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering: Prospect for Precision Folic Acid Treatment.Semantic proximity Read ↗

Red cell N5-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke.Semantic proximity Read ↗

TT genotype of the methylenetetrahydrofolate reductase C677T polymorphism is an important determinant for homocysteine levels in multi-ethnic Malaysian ischaemic stroke patients.Semantic proximity Read ↗

Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphism in Indian stroke patients.Semantic proximity Read ↗

The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.