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Article

Optimal folic acid dosage in lowering homocysteine: Precision Folic Acid Trial to lower homocysteine (PFAT-Hcy).

European journal of nutrition - 1 Aug 2024

Huang Xiao, Bao Huihui, Ding Congcong, Li Junpei, Cao Tianyu, Liu Lishun, Wei Yaping, Zhou Ziyi, Zhang Nan, Song Yun, Chen Ping, Jiang Chongfei, Xie Liling, Qin Xianhui, Zhang Yan, Li Jianping, Sun Ningling, Tang Genfu, Wang Xiaobin, Wang Hong, Huo Yong, Cheng Xiaoshu

Abstract excerpt

BACKGROUND: While folic acid (FA) is widely used to treat elevated total homocysteine (tHcy), promoting vascular health by reducing vascular oxidative stress and modulating endothelial nitric oxide synthase, the optimal daily dose and individual variation by MTHFR C677T genotypes have not been well studied. Therefore, this study aimed to explore the efficacy of eight different FA dosages on tHcy lowering in the...

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Identifiers

PMID: 38478042
DOI: 10.1007/s00394-024-03344-8
PMCID: PMC11329420

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