Article
Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish.
Development (Cambridge, England) - 1 Nov 1997
Chen J N, van Eeden F J, Warren K S, Chin A, Nüsslein-Volhard C, Haffter P, Fishman M C
Abstract excerpt
The first evident break in left-right symmetry of the primitive zebrafish heart tube is the shift in pattern of BMP4 expression from radially symmetric to left-predominant. The midline heart tube then 'jogs' to the left and subsequently loops to the right. We examined 279 mutations, affecting more than 200 genes, and found 21 mutations that perturb this process. Some cause BMP4 to remain radially symmetric....
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