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Article

Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish.

Development (Cambridge, England) - 1 Nov 1997

Chen J N, van Eeden F J, Warren K S, Chin A, Nüsslein-Volhard C, Haffter P, Fishman M C

Abstract excerpt

The first evident break in left-right symmetry of the primitive zebrafish heart tube is the shift in pattern of BMP4 expression from radially symmetric to left-predominant. The midline heart tube then 'jogs' to the left and subsequently loops to the right. We examined 279 mutations, affecting mor...

Topics

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Mutation
Signal Transduction
Gene Expression Regulation, Developmental
Embryo, Nonmammalian
Myocardium
Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bone Morphogenetic Proteins

Source

Identifiers

PMID: 9334285
DOI: 10.1242/dev.124.21.4373

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9334285-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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