Article
A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse.
Developmental biology - 1 Jun 1997
Yamamura H, Zhang M, Markwald R R, Mjaatvedt C H
Abstract excerpt
A recessive lethal insertional mutation on chromosome 13 has been identified in a transgenic mouse line that displays a segmental form of cardiac defect along the anterior-posterior axis in all homozygous mice identified. The most anterior segment (future conus and right ventricle) of the single heart tube fails to develop normally and the endocardial cushions in both the conus and the atrioventricular regions...
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