Article
Developmental spectrum of cardiac outflow tract anomalies encompassing transposition of the great arteries and dextroposition of the aorta: pathogenic effect of extrinsic retinoic acid in the mouse embryo.
The Anatomical record - 1 Feb 1999
Yasui H, Morishima M, Nakazawa M, Ando M, Aikawa E
Abstract excerpt
We previously reported that retinoic acid shows a dose-dependent differential induction of various cardiac outflow anomalies: transposition of the great arteries is induced mainly by a high dose (70 mg/kg) and dextroposition of the aorta by a low dose (40-60 mg/kg; Yasui et al., 1995). We subsequ...
Topics
- Animals
- Dose-Response Relationship, Drug
- Female
- Male
- Mice
- Mice, Inbred ICR
- Microscopy, Electron, Scanning
- Microscopy, Video
- Phenotype
- Pregnancy
- Transposition of Great Vessels
- Tretinoin