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Article

Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom.

Biochemistry - 10 Jun 1997

Lu Z, MacKinnon R

Abstract excerpt

We have purified a protein inhibitor of an inward-rectifier K+ channel, ROMK1, from the venom of the scorpion Leiurus quinquestriatus var. hebraeus. The inhibitor is Lq2, a previously discovered blocker of voltage- and Ca2+-activated K+ channels. Mutations were made on the channel and the inhibitor, and the resulting effects were examined using an electrophysiological assay. The data show that Lq2 blocks the pore...

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PMID: 9188688
DOI: 10.1021/bi9702849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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