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Article

Mapping the interaction surface of scorpion β-toxins with an insect sodium channel.

The Biochemical journal - 30 Jul 2021

Zhorov Boris S, Du Yuzhe, Song Weizhong, Luo Ningguang, Gordon Dalia, Gurevitz Michael, Dong Ke

Abstract excerpt

The interaction of insect-selective scorpion depressant β-toxins (LqhIT2 and Lqh-dprIT3 from Leiurus quinquestriatus hebraeus) with the Blattella germanica sodium channel, BgNav1-1a, was investigated using site-directed mutagenesis, electrophysiological analyses, and structural modeling. Focusing on the pharmacologically defined binding site-4 of scorpion β-toxins at the voltage-sensing domain II (VSD-II), we...

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Identifiers

PMID: 34195804
DOI: 10.1042/BCJ20210336
PMCID: PMC10081811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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