Article
Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned.
Molecular pharmacology - 1 Nov 2007
Cohen Lior, Troub Yael, Turkov Michael, Gilles Nicolas, Ilan Nitza, Benveniste Morris, Gordon Dalia, Gurevitz Michael
Abstract excerpt
Among scorpion beta- and alpha-toxins that modify the activation and inactivation of voltage-gated sodium channels (Na(v)s), depressant beta-toxins have traditionally been classified as anti-insect selective on the basis of toxicity assays and lack of binding and effect on mammalian Na(v)s. Here we show that the depressant beta-toxins LqhIT2 and Lqh-dprIT3 from Leiurus quinquestriatus hebraeus (Lqh) bind with...
Topics
- Amino Acid Sequence
- Animals
- Molecular Sequence Data
- Muscle Proteins
- Muscle, Skeletal
- Mutation
- Oocytes
- Rats
- Scorpion Venoms
- Sodium Channels
- Xenopus laevis