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Article

Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned.

Molecular pharmacology - 1 Nov 2007

Cohen Lior, Troub Yael, Turkov Michael, Gilles Nicolas, Ilan Nitza, Benveniste Morris, Gordon Dalia, Gurevitz Michael

Abstract excerpt

Among scorpion beta- and alpha-toxins that modify the activation and inactivation of voltage-gated sodium channels (Na(v)s), depressant beta-toxins have traditionally been classified as anti-insect selective on the basis of toxicity assays and lack of binding and effect on mammalian Na(v)s. Here we show that the depressant beta-toxins LqhIT2 and Lqh-dprIT3 from Leiurus quinquestriatus hebraeus (Lqh) bind with...

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PMID: 17720763
DOI: 10.1124/mol.107.039057

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