Article
An ERG channel inhibitor from the scorpion Buthus eupeus.
The Journal of biological chemistry - 30 Mar 2001
Korolkova Y V, Kozlov S A, Lipkin A V, Pluzhnikov K A, Hadley J K, Filippov A K, Brown D A, Angelo K, Strøbaek D, Jespersen T, Olesen S P, Jensen B S, Grishin E V
Abstract excerpt
The isolation of the peptide inhibitor of M-type K(+) current, BeKm-1, from the venom of the Central Asian scorpion Buthus eupeus has been described previously (Fillipov A. K., Kozlov, S. A., Pluzhnikov, K. A., Grishin, E. V., and Brown, D. A. (1996) FEBS Lett. 384, 277-280). Here we report the cloning, expression, and selectivity of BeKm-1. A full-length cDNA of 365 nucleotides encoding the precursor of BeKm-1...
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