Article
A novel conus peptide ligand for K+ channels.
The Journal of biological chemistry - 24 Jan 2003
Ferber Michael, Sporning Annett, Jeserich Gunnar, DeLaCruz Richard, Watkins Maren, Olivera Baldomero M, Terlau Heinrich
Abstract excerpt
Voltage-gated ion channels determine the membrane excitability of cells. Although many Conus peptides that interact with voltage-gated Na(+) and Ca(2+) channels have been characterized, relatively few have been identified that interact with K(+) channels. We describe a novel Conus peptide that interacts with the Shaker K(+) channel, kappaM-conotoxin RIIIK from Conus radiatus. The peptide was chemically...
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