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Article

Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.

Journal of virology - 1 Jun 1995

Campbell K S, Auger K R, Hemmings B A, Roberts T M, Pallas D C

Abstract excerpt

Two subunits of protein phosphatase 2A (PP2A) have been shown previously to bind to the small t and middle T antigens (ST and MT, respectively) of polyomavirus. To determine sequences important for binding of PP2A to ST and MT, we first constructed a series of ST mutants in regions known to be important for biological activity of ST and MT. Several mutations in two small regions just amino terminal to the...

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Identifiers

PMID: 7538174
DOI: 10.1128/JVI.69.6.3721-3728.1995
PMCID: PMC189088

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