Article
The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted
1 Jul 1997
Abstract excerpt
Naturally occurring deletions in the hepatitis B virus pre-S1 domain have been frequently found during persistent viral infection. In this study we have investigated the functional properties of a mutant viral genome that carries an in-frame deletion of 183 nucleotides in the pre-S1 region. This deletion removes the promoter of the small envelope gene. Transfection into human hepatocellular carcinoma cells of a...
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