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Article

Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes

1 Sept 1994

Abstract excerpt

Hepadnaviruses cause persistent noncytopathic infections of hepatocytes in humans and other animals. Virus replication depends on the pool of viral covalently closed circular DNA (cccDNA) molecules, which serve as transcriptional templates in the nuclei of infected cells. The size of this pool of cccDNA molecules is regulated by the ability of the large envelope protein of the virus to direct newly synthesized...

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PMID: 8057452
DOI: 10.1128/jvi.68.9.5706-5713.1994

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