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Article

The pre-s2 domain of the hepatitis B virus is dispensable for infectivity but serves a spacer function for L-protein-connected virus assembly.

Journal of virology - 1 Apr 2010

Ni Yi, Sonnabend Jessika, Seitz Stefan, Urban Stephan

Abstract excerpt

The envelope of the human hepatitis B virus (HBV) contains three membrane proteins (L, M, and S). They accomplish different functions in HBV infectivity and nucleocapsid envelopment. Infectivity determinants have been assigned to the N-terminal part of the pre-S1 domain of the L protein and the antigenic loop of the S domain in the L and/or S protein. Nucleocapsid envelopment requires a C-terminal sequence within...

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Identifiers

PMID: 20130049
DOI: 10.1128/JVI.02528-09
PMCID: PMC2849487

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Source receipt: pubmed, retrieved 7 Sept 2026.

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