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Article

The shiverer mutation affects the persistence of Theiler's virus in the central nervous system.

Journal of virology - 1 Jul 1997

Bihl F, Pena-Rossi C, Guénet J L, Brahic M, Bureau J F

Abstract excerpt

Theiler's virus persists in the white matter of the spinal cord of genetically susceptible mice and causes primary demyelination. The virus persists in macrophages/microglial cells, but also in oligodendrocytes, the myelin-forming cells. Susceptibility/resistance to this chronic infection has been mapped to several loci including one tentatively located in the telomeric region of chromosome 18, close to the...

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Source

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Identifiers

PMID: 9188567
DOI: 10.1128/JVI.71.7.5025-5030.1997
PMCID: PMC191735

Genes

MBP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The shiverer mutation affects the persistence of Theiler's virus in the central nervous system.PMID 9188567Read ↗

The role of myelin in Theiler's virus persistence in the central nervous system.Semantic proximity Read ↗

Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.Semantic proximity Read ↗

The genetics of the persistent infection and demyelinating disease caused by Theiler's virus.Semantic proximity Read ↗

Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.Semantic proximity Read ↗

The infection of mouse by Theiler's virus: from genetics to immunology.Semantic proximity Read ↗

The dysmyelinating mouse mutations shiverer (shi) and myelin deficient (shimld).Semantic proximity Read ↗

Molecular biology of myelin basic protein: gene rearrangement and expression of anti-sense RNA in myelin-deficient mutants.Semantic proximity Read ↗

Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus.Semantic proximity Read ↗

Genetics of susceptibility to Theiler's virus infection.Semantic proximity Read ↗

The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.Semantic proximity Read ↗

Quaking*shiverer double-mutant mice survive for at least 100 days with no CNS myelin.Semantic proximity Read ↗

H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virus.Semantic proximity Read ↗

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