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Article

Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.

Nature genetics - 1 Sept 1993

Bureau J F, Montagutelli X, Bihl F, Lefebvre S, Guénet J L, Brahic M

Abstract excerpt

Inbred strains of mice differ greatly in their susceptibility to the demyelinating disease caused by Theiler's Murine Encephalomyelitis Virus. In this murine disease, which is an animal model for the study of multiple sclerosis, demyelination depends on the persistent infection of the central nervous system. Previous studies identified a locus in the H-2D region of the major histocompatibility complex which...

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Source

Identifiers

PMID: 8220433
DOI: 10.1038/ng0993-87

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.PMID 8220433Read ↗

Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.Semantic proximity Read ↗

The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.Semantic proximity Read ↗

The genetics of the persistent infection and demyelinating disease caused by Theiler's virus.Semantic proximity Read ↗

Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus.Semantic proximity Read ↗

Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse.Semantic proximity Read ↗

The infection of mouse by Theiler's virus: from genetics to immunology.Semantic proximity Read ↗

Genetics of susceptibility to Theiler's virus infection.Semantic proximity Read ↗

The shiverer mutation affects the persistence of Theiler's virus in the central nervous system.Semantic proximity Read ↗

Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.Semantic proximity Read ↗

Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon.Semantic proximity Read ↗

Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis.Semantic proximity Read ↗

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