The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.

doi:10.1128/JVI.66.8.4698-4704.1992

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Article

The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.

Journal of virology - 1 Aug 1992

Bureau J F, Montagutelli X, Lefebvre S, Guénet J L, Pla M, Brahic M

Abstract excerpt

Theiler's murine encephalomyelitis virus is responsible for a chronic inflammatory demyelinating disease of the central nervous system of the mouse. The disease is associated with persistent viral infection of the spinal cord. Some strains of mice are susceptible to viral infection, and other strains are resistant. The effect of the genetic background of the host on viral persistence has not been thoroughly...

Topics

Animals
Brain
Chromosome Mapping
Crosses, Genetic
DNA
DNA, Viral
Genetic Predisposition to Disease
H-2 Antigens
Major Histocompatibility Complex
Maus Elberfeld virus
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Polymerase Chain Reaction

RNA

RNA, Viral

Species Specificity

Spinal Cord

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 1378508
DOI: 10.1128/JVI.66.8.4698-4704.1992
PMCID: PMC241295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1378508-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.PMID 1378508Read ↗

Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.Semantic proximity Read ↗

Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.Semantic proximity Read ↗

The genetics of the persistent infection and demyelinating disease caused by Theiler's virus.Semantic proximity Read ↗

Bone marrow chimeras reveal non-H-2 hematopoietic control of susceptibility to Theiler's virus persistent infection.Semantic proximity Read ↗

The infection of mouse by Theiler's virus: from genetics to immunology.Semantic proximity Read ↗

Genetics of susceptibility to Theiler's virus infection.Semantic proximity Read ↗

Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus.Semantic proximity Read ↗

Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.Semantic proximity Read ↗

CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.Semantic proximity Read ↗

Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon.Semantic proximity Read ↗

Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.Semantic proximity Read ↗

The shiverer mutation affects the persistence of Theiler's virus in the central nervous system.Semantic proximity Read ↗

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