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Article

Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.

Science (New York, N.Y.) - 20 Jun 1997

Richards S A, Carey K L, Macara I G

Abstract excerpt

A leucine-rich nuclear export signal (NES) allows rapid export of proteins from cell nuclei. Microinjection studies revealed a role for the guanosine triphosphatase (GTPase) Ran in NES-mediated export. Nuclear injection of a Ran mutant (Thr24 --> Asn) blocked protein export but not import, whereas depletion of the Ran nucleotide exchange factor RCC1 blocked protein import but not export. However, injection of Ran...

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Source

Identifiers

PMID: 9188526
DOI: 10.1126/science.276.5320.1842

Genes

NES
RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.PMID 9188526Read ↗

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RanGAP1 induces GTPase activity of nuclear Ras-related Ran.Semantic proximity Read ↗

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.Semantic proximity Read ↗

Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.Semantic proximity Read ↗

Identification and characterization of three novel nuclear export signals in the influenza A virus nucleoprotein.Semantic proximity Read ↗

Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.Semantic proximity Read ↗

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Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.Semantic proximity Read ↗

GTP hydrolysis by Ran is required for nuclear envelope assembly.Semantic proximity Read ↗

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