Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.

doi:10.1126/science.276.5320.1842

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Article

Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.

Science (New York, N.Y.) - 20 Jun 1997

Richards S A, Carey K L, Macara I G

Abstract excerpt

A leucine-rich nuclear export signal (NES) allows rapid export of proteins from cell nuclei. Microinjection studies revealed a role for the guanosine triphosphatase (GTPase) Ran in NES-mediated export. Nuclear injection of a Ran mutant (Thr24 --> Asn) blocked protein export but not import, wherea...

Topics

Animals
Biological Transport
Carrier Proteins
Cell Cycle Proteins
Cell Line
Cell Nucleus
Cricetinae
Cytoplasm
DNA-Binding Proteins
GTP Phosphohydrolases
GTP-Binding Proteins
GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutathione Transferase

Green Fluorescent Proteins

Guanine Nucleotide Exchange Factors

Guanosine Triphosphate

Luminescent Proteins

Mutation

Source

Open in PubMed

Identifiers

PMID: 9188526
DOI: 10.1126/science.276.5320.1842

Genes

NES
RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9188526-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.PMID 9188526Read ↗

A Ran-independent pathway for export of spliced mRNA.Semantic proximity Read ↗

Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.Semantic proximity Read ↗

Nuclear export of signal recognition particle RNA in mammalian cells.Semantic proximity Read ↗

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.Semantic proximity Read ↗

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.Semantic proximity Read ↗

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.Semantic proximity Read ↗

Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.Semantic proximity Read ↗

Identification and characterization of three novel nuclear export signals in the influenza A virus nucleoprotein.Semantic proximity Read ↗

Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.Semantic proximity Read ↗

Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin.Semantic proximity Read ↗

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.Semantic proximity Read ↗

GTP hydrolysis by Ran is required for nuclear envelope assembly.Semantic proximity Read ↗

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