Article
Nuclear export of signal recognition particle RNA in mammalian cells.
Biochemical and biophysical research communications - 9 Jan 2004
Alavian Christina N, Politz Joan C Ritland, Lewandowski Laura B, Powers Christine M, Pederson Thoru
Abstract excerpt
In mammalian cells the signal recognition particle (SRP) consists of a approximately 300 nucleotide RNA and six proteins. Although the molecular structure and functional cycle of the SRP are both very well understood, far less is known about how the SRP is first assembled in the cell. Recent work has suggested that SRP assembly begins in the nucleoli. When NRK (rat fibroblast) cells were treated with leptomycin B...
Topics
- Active Transport, Cell Nucleus
- Animals
- Cell Line
- Cell Nucleolus
- Cricetinae
- Fatty Acids, Unsaturated
- Fibroblasts
- Guanine Nucleotide Exchange Factors
- Humans
- In Situ Hybridization
- Mutation
- Oligonucleotide Probes
- RNA
- RNA, Ribosomal, 28S
- Rats
- Signal Recognition Particle
- Temperature
- ran GTP-Binding Protein