Article
Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.
The EMBO journal - 16 Dec 1996
Weis K, Dingwall C, Lamond A I
Abstract excerpt
The small nuclear GTP binding protein Ran is required for transport of nuclear proteins through the nuclear pore complex (NPC). Although it is known that GTP hydrolysis by Ran is essential for this reaction, it has been unclear whether additional energy-consuming steps are also required. To uncou...
Topics
- Binding Sites
- Biological Transport
- Mutation
- Nuclear Proteins
- Nucleotides
- ran GTP-Binding Protein