Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis.

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Article

Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis.

Cancer research - 1 Jun 1997

Tkachenko A, Ashar H R, Meloni A M, Sandberg A A, Chada K K

Abstract excerpt

Cancer arises from aberrations in the genetic mechanisms that control growth and differentiation. HMGI-C and HMGI(Y) are members of the HMGI family of architectural factors expressed in embryonic or undifferentiated cells and highly associated with transformation. Translocations of 12q13-15 in li...

Topics

Alleles
Cell Differentiation
Chromosomes, Human, Pair 6
Gene Expression Regulation, Neoplastic
Gene Rearrangement
HMGA1a Protein
High Mobility Group Proteins
Humans
Karyotyping
Lipoma
Mutagenesis
Recombinant Fusion Proteins
Sequence Deletion
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 9187132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9187132-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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