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Article

Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis.

Cancer research - 1 Jun 1997

Tkachenko A, Ashar H R, Meloni A M, Sandberg A A, Chada K K

Abstract excerpt

Cancer arises from aberrations in the genetic mechanisms that control growth and differentiation. HMGI-C and HMGI(Y) are members of the HMGI family of architectural factors expressed in embryonic or undifferentiated cells and highly associated with transformation. Translocations of 12q13-15 in lipomas (fat cell tumors) disrupt HMGI-C and fuse its DNA-binding domains to novel transcriptional regulatory domains....

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PMID: 9187132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis.PMID 9187132Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

HMGA2 is expressed in an allele-specific manner in human lipomas.Semantic proximity Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>Semantic proximity Read ↗

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasSemantic proximity Read ↗

The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype.Semantic proximity Read ↗

Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas.Semantic proximity Read ↗

Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroupsSemantic proximity Read ↗

HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumorsSemantic proximity Read ↗

Misexpression of Full-length HMGA2 Induces Benign Mesenchymal Tumors in MiceSemantic proximity Read ↗

Coordinated expression and amplification of theMDM2,CDK4, andHMGI-C genes in atypical lipomatous tumoursSemantic proximity Read ↗

Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts.Semantic proximity Read ↗

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