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Article

Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>

1 Mar 1998

Abstract excerpt

The high-mobility group (HMG) proteins are a family of nonhistone chromatin-associated proteins that have an important role in regulating chromatin architecture, as well as in regulating gene expression. The gene encoding one HMG protein, HMGI-C, is frequently rearranged or overexpressed by chromosomal translocations in common benign mesenchymal tumors including lipomas, leiomyomas, fibroadenomas, pleomorphic...

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PMID: 9495195
DOI: 10.1093/ajcp/109.3.251

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Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>PMID 9495195Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumorsSemantic proximity Read ↗

Roles of HMGA proteins in cancer.Semantic proximity Read ↗

Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis.Semantic proximity Read ↗

Chromosomal translocation t(8;12) induces aberrant <i>HMGIC</i> expression in aggressive angiomyxoma of the vulvaSemantic proximity Read ↗

Frequency and characterization of <i>HMGA2</i> and <i>HMGA1</i> rearrangements in mesenchymal tumors of the lower genital tractSemantic proximity Read ↗

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasSemantic proximity Read ↗

Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas.Semantic proximity Read ↗

HMGA1 in cancer: Cancer classification by locationSemantic proximity Read ↗

Role of the high mobility group A proteins in human lipomasSemantic proximity Read ↗

High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial NeoplasiaSemantic proximity Read ↗

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