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Article

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas

1 Sept 1996

Abstract excerpt

Uterine leiomyomata are the most common pelvic tumors in women and are the indication for more than 200,000 hysterectomies annually in the United States. Rearrangement of chromosome 12 in bands q14-q15 is characteristic of uterine leiomyomata and other benign mesenchymal tumors, and we identified a yeast artificial chromosome (YAC) spanning chromosome 12 translocation breakpoints in a uterine leiomyoma, a...

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PMID: 8889500
DOI: 10.1002/(sici)1098-2264(199609)17:1<1::aid-gcc1>3.0.co;2-0

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Related research

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Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasPMID 8889500Read ↗

Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas.Semantic proximity Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

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HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumorsSemantic proximity Read ↗

Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>Semantic proximity Read ↗

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HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

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Fusion of a Sequence from HEI10 (14q11) to the HMGIC Gene at 12ql5 in a Uterine LeiomyomaSemantic proximity Read ↗

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