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Article

The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype.

Genes, chromosomes & cancer - 1 Jun 1998

Rogalla P, Kazmierczak B, Meyer-Bolte K, Tran K H, Bullerdiek J

Abstract excerpt

The HMGIC gene, located in chromosome band 12q15, is rearranged in many different benign human tumors, often resulting in its fusion to ectopic sequences from other genes. The t(3;12)(q27;q14-q15) fuses HMGIC with the LPP gene and has so far been described exclusively in lipomas. Thus, it can be hypothesized that this particular gene fusion determines the adipocytic differentiation. We studied five pulmonary...

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Source

Identifiers

PMID: 9598796
DOI: 10.1002/(sici)1098-2264(199806)22:2<100::aid-gcc3>3.0.co;2-0

Genes

LPP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype.PMID 9598796Read ↗

Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis.Semantic proximity Read ↗

Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas.Semantic proximity Read ↗

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasSemantic proximity Read ↗

Novel gene fusion ofCOX6C at 8q22-23 toHMGIC at 12q15 in a uterine leiomyomaSemantic proximity Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumorsSemantic proximity Read ↗

Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas.Semantic proximity Read ↗

HMGA2 is expressed in an allele-specific manner in human lipomas.Semantic proximity Read ↗

Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroupsSemantic proximity Read ↗

Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>Semantic proximity Read ↗

Rearrangements of chromosome bands 15q12-q21 are secondary to HMGA2 deregulation in conventional lipoma.Semantic proximity Read ↗

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