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Article

Misexpression of Full-length HMGA2 Induces Benign Mesenchymal Tumors in Mice

1 Aug 2006

Abstract excerpt

The high-mobility group AT-hook 2 (HMGA2) protein is a member of the high-mobility group family of the DNA-binding architectural factors and participates in the conformational regulation of active chromatin on its specific downstream target genes. HMGA2 is expressed in the undifferentiated mesenchyme and is undetectable in their differentiated counterparts, suggesting its functional importance in mesenchymal...

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PMID: 16885341
DOI: 10.1158/0008-5472.can-06-0931

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