Article
HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 2000
Tallini G, Vanni R, Manfioletti G, Kazmierczak B, Faa G, Pauwels P, Bullerdiek J, Giancotti V, Van Den Berghe H, Dal Cin P
Abstract excerpt
High-mobility group (HMG) proteins are nonhistone nuclear proteins that play an important role in the regulation of chromatin structure and function. HMGI-C and HMGI(Y) are members of the HMGI family of HMG proteins, and their expression in adult tissues generally correlates with malignant tumor phenotypes. However, HMGI-C and HMGI(Y) dysregulation as a result of specific rearrangements involving 12q15 and 6p21,...
Topics
- Chromosome Aberrations
- Chromosome Disorders
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 6
- Endometrial Neoplasms
- Female
- Gene Rearrangement
- HMGA1a Protein
- HMGA2 Protein