Article
Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.
Cancer research - 1 Nov 1997
Zhuang Z, Vortmeyer A O, Pack S, Huang S, Pham T A, Wang C, Park W S, Agarwal S K, Debelenko L V, Kester M, Guru S C, Manickam P, Olufemi S E, Yu F, Heppner C, Crabtree J S, Skarulis M C, Venzon D J, Emmert-Buck M R, Spiegel A M, Chandrasekharappa S C, Collins F S, Burns A L, Marx S J, Lubensky I A
Abstract excerpt
Gastrinomas and insulinomas are frequent in multiple endocrine neoplasia type 1 (MEN1). The MEN1 tumor suppressor gene was recently identified. To elucidate the etiological role of the MEN1 gene in sporadic enteropancreatic endocrine tumorigenesis, we analyzed tumors (28 gastrinomas and 12 insulinomas) from 40 patients for MEN1 gene mutations and allelic deletions. One copy of the MEN1 gene was found to be...
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